| The Chromosome 7 Annotation Project |
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene / Transcript Structure |
| General information |
| Class | Known_Gene |
| TCAG Gene ID | GA0077 [Old ID: HSC7000077] |
| Gene Symbol | DLX5 [HUGO ID: DLX5] |
| Gene Name | Distal-less homeo box 5 |
| Synonyms | |
| Summary | Summary: Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. DLX5 and DLX6 are closely linked in an inverted convergent (tail-to-tail) configuration. DLX5 is a candidate gene for split-hand/split-foot malformation (SHFM1). |
| Omim | Distal-less homeo box-5 | 600028 |
| Gene Ontology | ●Biological process Development [GO:0007275] Neurogenesis [GO:0007399] Regulation of transcription, DNA-dependent [GO:0006355] Skeletal development [GO:0001501] ●Cellular component Nucleus [GO:0005634] ●Molecular function Transcription factor activity [GO:0003700] |
| Transcript | DLX5 | T00077 | BC006226.2 |
| External links |
| LocusLink | 1749 |
| RefSeq | NM_005221 | NP_005212 |
| GenBank | AC004774 [genome] AK023493 [mRNA] BC006226 [mRNA] |
| PubMed | 14702039, 12782124, 12477932, 11959851, 7987313, 7907794 |
| ABI Gene Expression "Assays-on-Demand" | Hs00193291_m1 |
| Affymetrix GeneChip | U133A U95A|41087_at |
| Transcript Sequence(s) |
Note: Some data originated from NCBI's LocusLink.