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| The Chromosome 7 Annotation Project |
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| Gene / Transcript Structure |
| General information |
| Class | Known_Gene |
| TCAG Gene ID | GA0132 [Old ID: HSC7000132] |
| Gene Symbol | GRB10 [HUGO ID: GRB10] |
| Gene Name | Growth factor receptor-bound protein 10 |
| Synonyms | GRB-IR, IRBP, KIAA0207, MEG1, RSS |
| Summary | Summary: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Omim | Growth factor receptor-bound protein-10 | 601523 |
| Gene Ontology | ●Biological process Cell-cell signaling [GO:0007267] Insulin receptor signaling pathway [GO:0008286] Intracellular signaling cascade [GO:0007242] ●Cellular component Cytoplasm [GO:0005737] Plasma membrane [GO:0005886] ●Molecular function SH3/SH2 adaptor protein activity [GO:0005070] |
| Transcript | GRB10 | T00111 | D86962.1 GRB10_transcript_variant_1 | T02814 | AJ271366.1 GRB10_transcript_variant_2 | T02815 | BC024285.1 GRB10_transcript_variant_3 | T02816 | BX649028.1 |
| External links |
| Transcript Sequence(s) |
Note: Some data originated from NCBI's LocusLink.