The Chromosome 7 Annotation Project
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TCAG Gene Summary: GRM3 [GA0133]

Gene / Transcript Structure
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General information
Class Known_Gene
TCAG Gene ID GA0133 [Old ID: HSC7000133]
Gene Symbol GRM3 [HUGO ID: GRM3]
Gene Name Glutamate receptor, metabotropic 3
Synonyms GLUR3, GPRC1C, MGLUR3, mGlu3
Summary Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Omim Glutamate receptor, metabotropic-3 | 601115
Gene Ontology ●Biological process
   G-protein coupled receptor protein signaling pathway [GO:0007186]
   Negative regulation of adenylate cyclase activity [GO:0007194]
   Synaptic transmission [GO:0007268]
●Cellular component
   Integral to plasma membrane [GO:0005887]
●Molecular function
   Metabotropic glutamate, GABA-B-like receptor activity [GO:0008067]
Transcript GRM3 | T00112 | BC041407.1
External links
LocusLink 2913
RefSeq NM_000840 | NP_000831
GenBank AC002081 [genome]
BC022496 [mRNA]
BC041407 [mRNA]

X77748 [mRNA]
PubMed 12786977, 12782962, 12477932, 11840505, 11744707, 11500049, 11342382, 8887960, 8840013, 8824806
ABI Gene Expression "Assays-on-Demand™" Hs00168260_m1
Affymetrix GeneChip U133A
U95A|39928_at
Transcript Sequence(s)
>T00112 Gene_ID:GA0133,Symbol:GRM3,Class:Known_Gene,BaseSeq:BC041407.1
AGCGGAGGTGCAGTTGAGTCGCGAGTACGGCTGAGCTGCGTACCGGCCTCCCTGGCTCTCACACTCCCTCTCTGCTCCCG
CTCTCCTAATCTCCTCTGGCATGCGGTCAGCCCCCTGCCCAGGGACCACAGGAGAGTTCTTGTAAGGACTGTTAGTCCCT
GCTTACCTGAAAGCCAAGCGCTCTAGCAGAGCTTTAAAGTTGGAGCCGCCACCCTCCCTACCGCCCCATGCCCCTTCACC
CCACTCCGAAATTCACCGACCTTTGCATGCACTGCCTAAGGATTTCAGAGTGAGGCAAAGCAGTCGGCAAATCTACCCTG
GCTTTTCGTATAAAAATCCTCTCGTCTAGGTACCCTGGCTCACTGAAGACTCTGCAGATATACCCTTATAAGAGGGAGGG
TGGGGGAGGGAAAAGAACGAGAGAGGGAGGAAAGAATGAAAAGGAGAGGATGCCAGGAGGTCCGTGCTTCTGCCAAGAGT
CCCAATTAGATGCGACGGCTTCAGCCTGGTCAAGGTGAAGGAAAGTTGCTTCCGCGCCTAGGAAGTGGGTTTGCCTGATA
AGAGAAGGAGGAGGGGACTCGGCTGGGAAGAGCTCCCCTCCCCTCCGCGGAAGACCACTGGGTCCCCTCTTTCCCCAACC
TCCTCCCTCTCTTCTACTCCACCCCTCCGTTTTCCCACTCCCCACTGACTCGGATGCCTGGATGTTCTGCCACCGGGCAG
TGGTCCAGCGTGCAGCCGGGAGGGGGCAGGGGCAGGGGGCACTGTGACAGGAAGCTGCGCGCACAAGTTGGCCATTTCGA
GGGCAAAATAAGTTCTCCCTTGGATTTGGAAAGGACAAAGCCAGTAAGCTACCTCTTTTGTGTCGGATGAGGAGGACCAA
CCATGAGCCAGAGCCCGGGTGCAGGCTCACCGCCGCCGCTGCCACCGCGGTCAGCTCCAGTTCCTGCCAGGAGTTGTCGG
TGCGAGGAATTTTGTGACAGGCTCTGTTAGTCTGTTCCTCCCTTATTTGAAGGACAGGCCAAAGATCCAGTTTGGAAATG
AGAGAGGACTAGCATGACACATTGGCTCCACCATTGATATCTCCCAGAGGTACAGAAACAGGATTCATGAAGATGTTGAC
AAGACTGCAAGTTCTTACCTTAGCTTTGTTTTCAAAGGGATTTTTACTCTCTTTAGGGGACCATAACTTTCTAAGGAGAG
AGATTAAAATAGAAGGTGACCTTGTTTTAGGGGGCCTGTTTCCTATTAACGAAAAAGGCACTGGAACTGAAGAATGTGGG
CGAATCAATGAAGACCGAGGGATTCAACGCCTGGAAGCCATGTTGTTTGCTATTGATGAAATCAACAAAGATGATTACTT
GCTACCAGGAGTGAAGTTGGGTGTTCACATTTTTGATACATGTTCAAGGGATACCTATGCATTGGAGCAATCACTGGAGT
TTGTCAGGGCATCTTTGACAAAAGTGGATGAAGCTGAGTATATGTGTCCTGATGGATCCTATGCCATTCAAGAAAACATC
CCACTTCTCATTGCAGGGGTCATTGGTGGCTCTTATAGCAGTGTTTCCATACAGGTGGCAAACCTGCTGCGGCTCTTCCA
GATCCCTCAGATCAGCTACGCATCCACCAGCGCCAAACTCAGTGATAAGTCGCGCTATGATTACTTTGCCAGGACCGTGC
CCCCCGACTTCTACCAGGCCAAAGCCATGGCTGAGATCTTGCGCTTCTTCAACTGGACCTACGTGTCCACAGTAGCCTCC
GAGGGTGATTACGGGGAGACAGGGATCGAGGCCTTCGAGCAGGAAGCCCGCCTGCGCAACATCTGCATCGCTACGGCGGA
GAAGGTGGGCCGCTCCAACATCCGCAAGTCCTACGACAGCGTGATCCGAGAACTGTTGCAGAAGCCCAACGCGCGCGTCG
TGGTCCTCTTCATGCGCAGCGACGACTCGCGGGAGCTCATTGCAGCCGCCAGCCGCGCCAATGCCTCCTTCACCTGGGTG
GCCAGCGACGGCTGGGGCGCGCAGGAGAGCATCATCAAGGGCAGCGAGCATGTGGCCTACGGCGCCATCACCCTGGAGCT
GGCCTCCCAGCCTGTCCGCCAGTTCGACCGCTACTTCCAGAGCCTCAACCCCTACAACAACCACCGCAACCCCTGGTTCC
GGGACTTCTGGGAGCAAAAGTTTCAGTGCAGCCTCCAGAACAAACGCAACCACAGGCGCGTCTGCGACAAGCACCTGGCC
ATCGACAGCAGCAACTACGAGCAAGAGTCCAAGATCATGTTTGTGGTGAACGCGGTGTATGCCATGGCCCACGCTTTGCA
CAAAATGCAGCGCACCCTCTGTCCCAACACTACCAAGCTTTGTGATGCTATGAAGATCCTGGATGGGAAGAAGTTGTACA
AGGATTACTTGCTGAAAATCAACTTCACGGCTCCATTCAACCCAAATAAAGATGCAGATAGCATAGTCAAGTTTGACACT
TTTGGAGATGGAATGGGGCGATACAACGTGTTCAATTTCCAAAATGTAGGTGGAAAGTATTCCTACTTGAAAGTTGGTCA
CTGGGCAGAAACCTTATCGCTAGATGTCAACTCTATCCACTGGTCCCGGAACTCAGTCCCCACTTCCCAGTGCAGCGACC
CCTGTGCCCCCAATGAAATGAAGAATATGCAACCAGGGGATGTCTGCTGCTGGATTTGCATCCCCTGTGAACCCTACGAA
TACCTGGCTGATGAGTTTACCTGTATGGATTGTGGGTCTGGACAGTGGCCCACTGCAGACCTAACTGGATGCTATGACCT
TCCTGAGGACTACATCAGGTGGGAAGACGCCTGGGCCATTGGCCCAGTCACCATTGCCTGTCTGGGTTTTATGTGTACAT
GCATGGTTGTAACTGTTTTTATCAAGCACAACAACACACCCTTGGTCAAAGCATCGGGCCGAGAACTCTGCTACATCTTA
TTGTTTGGGGTTGGCCTGTCATACTGCATGACATTCTTCTTCATTGCCAAGCCATCACCAGTCATCTGTGCATTGCGCCG
ACTCGGGCTGGGGAGTTCCTTCGCTATCTGTTACTCAGCCCTGCTGACCAAGACAAACTGCATTGCCCGCATCTTCGATG
GGGTCAAGAATGGCGCTCAGAGGCCAAAATTCATCAGCCCCAGTTCTCAGGTTTTCATCTGCCTGGGTCTGATCCTGGTG
CAAATTGTGATGGTGTCTGTGTGGCTCATCCTGGAGGCCCCAGGCACCAGGAGGTATACCCTTGCAGAGAAGCGGGAAAC
AGTCATCCTAAAATGCAATGTCAAAGATTCCAGCATGTTGATCTCTCTTACCTACGATGTGATCCTGGTGATCTTATGCA
CTGTGTACGCCTTCAAAACGCGGAAGTGCCCAGAAAATTTCAACGAAGCTAAGTTCATAGGTTTTACCATGTACACCACG
TGCATCATCTGGTTGGCCTTCCTCCCTATATTTTATGTGACATCAAGTGACTACAGAGTGCAGACGACAACCATGTGCAT
CTCTGTCAGCCTGAGTGGCTTTGTGGTCTTGGGCTGTTTGTTTGCACCCAAGGTTCACATCATCCTGTTTCAACCCCAGA
AGAATGTTGTCACACACAGACTGCACCTCAACAGGTTCAGTGTCAGTGGAACTGGGACCACATACTCTCAGTCCTCTGCA
AGCACGTATGTGCCAACGGTGTGCAATGGGCGGGAAGTCCTCGACTCCACCACCTCATCTCTGTGATTGTGAATTGCAGT
TCAGTTCTTGTGTTTTTAGACTGTTAGACAAAAGTGCTCACGTGCAGCTCCAGAATATGGAAACAGAGCAAAAGAACAAC
CCTAGTACCTTTTTTTAGAAACAGTACGATAAATTATTTTTGAGGACTGTATATAGTGATGTGCTAGAACTTTCTAGGCT
GAGTCTAGTGCCCCTATTATTAACAATTCCCCCAGAACATGGAAATAACCATTGTTTACAGAGCTGAGCATTGGTGACAG
GGTCTGACATGGTCAGTCTACTAAAAAACAAAAAAAAAAAACAAAAAAAAAAAAACAAAAGAAAAAAATAAAAATACGGT
GGCAATATTATGTAACCTTTTTTCCTATGAAGTTTTTTGTAGGTCCTTGTTGTAACTAATTTAGGATGAGTTTCTATGTT
GTATATTAAAGTTACATTATGTGTAACAGATTGATTTTCTCAGCACAAAATAAAAAGCATCTGTATTAATGTAAAGATAC
TGAGAATAAAACCTTCAAGGTTTTCCAAAAAAAAAAAAAAAA

Note: Some data originated from NCBI's LocusLink.