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| The Chromosome 7 Annotation Project |
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| Gene / Transcript Structure |
| General information |
| Class | Known_Gene |
| TCAG Gene ID | GA0134 [Old ID: HSC7000134] |
| Gene Symbol | GRM8 [HUGO ID: GRM8] |
| Gene Name | Glutamate receptor, metabotropic 8 |
| Synonyms | GLUR8, GPRC1H, MGLUR8, mGlu8 |
| Summary | Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined. |
| Omim | Glutamate receptor, metabotropic-8 | 601116 |
| Gene Ontology | ●Cellular component Membrane [GO:0016020] ●Molecular function Metabotropic glutamate, GABA-B-like receptor activity [GO:0008067] |
| Transcript | GRM8 | T00113 | U92459.1 GRM8_transcript_variant_1 | T02412 | AJ236922.1 GRM8_transcript_variant_2 | T02817 | AK123053.1 |
| External links |
| LocusLink | 2918 |
| RefSeq | NM_000845 | NP_000836 |
| GenBank | AC000099 [genome] AJ236921 [mRNA] AJ236922 [mRNA] AY608335 [mRNA] U92459 [mRNA] U95025 [mRNA] |
| PubMed | 10216218, 9473604, 9299241, 8824806 |
| ABI Gene Expression "Assays-on-Demand™" | Hs00168299_m1 |
| Affymetrix GeneChip | U133A U95A|34007_at |
| Transcript Sequence(s) |
Note: Some data originated from NCBI's LocusLink.