| The Chromosome 7 Annotation Project |
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| Gene / Transcript Structure |
| General information |
| Class | Known_Gene |
| TCAG Gene ID | GA0164 [Old ID: HSC7000164] |
| Gene Symbol | IGFBP1 [HUGO ID: IGFBP1] |
| Gene Name | Insulin-like growth factor binding protein 1 |
| Synonyms | IBP1, IGF-BP25 |
| Summary | Summary: Unlike insulin, both IGF I (MIM 147440) and IGF II (MIM 147470) circulate in plasma tightly bound to specific binding proteins. Two major forms of IGF-binding proteins have been identified in human plasma, a low molecular weight form and a high molecular weight form. The low molecular weight IGF-binding protein (IGFBP1) is synthesized in liver, secretory endometrium, and decidua. It binds both IGF I and IGF II with high affinity.[supplied by OMIM] |
| Omim | Insulin-like growth factor-binding protein-1 | 146730 |
| Gene Ontology | ●Biological process Cell growth and/or maintenance [GO:0008151] Regulation of cell growth [GO:0001558] Signal transduction [GO:0007165] ●Cellular component Extracellular space [GO:0005615] ●Molecular function Insulin-like growth factor binding [GO:0005520] |
| Transcript | IGFBP1 | T00149 | NM_000596.1 |
| External links |
| LocusLink | 3484 |
| RefSeq | NM_000596 | NP_000587 |
| GenBank | BC035263 [mRNA] BC057806 [mRNA] M20841 [mRNA] M23592 [genome] M23593 [genome] M23594 [genome] M23595 [genome] M31145 [mRNA] M59316 [genome] M74587 [genome] X12385 [mRNA] X13405 [mRNA] Y00856 [mRNA] |
| PubMed | 15070959, 14764802, 14726451, 14715837, 14568572, 12933666, 12882925, 12870155, 12861174, 12843192, 12843178, 12746836, 12746292, 12679458, 12575534, 12571183, 12519841, 12493691, 12489207, 12477932, 12351482, 12163461, 12153746, 12150454, 12135130, 12082253, 12006706, 11972304, 11969341, 11956162, 11834727, 11793026, 11762714, 3419931, 2849945, 2478445, 2474129, 2461294, 2458522, 2457513, 2454104, 1701175, 1691735, 1373120 |
| ABI Gene Expression "Assays-on-Demand" | Hs00426285_m1 |
| Affymetrix GeneChip | U133A U133B U95A|1232_s_at |
| Transcript Sequence(s) |
Note: Some data originated from NCBI's LocusLink.