| The Chromosome 7 Annotation Project |
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| Gene / Transcript Structure |
| General information |
| Class | Known_Gene |
| TCAG Gene ID | GA0174 [Old ID: HSC7000174] |
| Gene Symbol | KCND2 [HUGO ID: KCND2] |
| Gene Name | Potassium voltage-gated channel, Shal-related subfamily, member 2 |
| Synonyms | KIAA1044, KV4.2, RK5 |
| Summary | Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. |
| Omim | Potassium voltage-gated channel, Shal-related subfamily, member 2 | 605410 |
| Gene Ontology | ●Biological process Cation transport [GO:0006812] Potassium ion transport [GO:0006813] ●Cellular component Integral to membrane [GO:0016021] Voltage-gated potassium channel complex [GO:0008076] ●Molecular function Voltage-gated potassium channel activity [GO:0005249] |
| Transcript | KCND2 | T00159 | AB028967.1 |
| External links |
| LocusLink | 3751 |
| RefSeq | NM_012281 | NP_036413 |
| GenBank | AB028967 [mRNA] AC004888 [genome] AF121104 [mRNA] AF142568 [genome] AF166007 [genome] AF166008 [genome] AJ010969 [mRNA] |
| PubMed | 14623880, 14559911, 10942109, 10729221, 10551270, 10470851 |
| ABI Gene Expression "Assays-on-Demand" | Hs00273378_m1 |
| Expression Data | KIAA1044 | Rt-PCR-ELISA |
| Affymetrix GeneChip | U133A U95A|32873_at |
| Transcript Sequence(s) |
Note: Some data originated from NCBI's LocusLink.