The Chromosome 7 Annotation Project
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TCAG Gene Summary: PDGFA [GA0213]

Gene / Transcript Structure
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General information
Class Known_Gene
TCAG Gene ID GA0213 [Old ID: HSC7000213]
Gene Symbol PDGFA [HUGO ID: PDGFA]
Gene Name Platelet-derived growth factor alpha polypeptide
Synonyms PDGF1
Summary Summary: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.
Omim Platelet-derived growth factor, alpha polypeptide | 173430
Gene Ontology ●Biological process
   Cell proliferation [GO:0008283]
   Cell surface receptor linked signal transduction [GO:0007166]
   Cell-cell signaling [GO:0007267]
   Regulation of cell cycle [GO:0000074]
●Cellular component
   Extracellular space [GO:0005615]
   Membrane [GO:0016020]
●Molecular function
   Growth factor activity [GO:0008083]
   Platelet-derived growth factor receptor binding [GO:0005161]
Transcript PDGFA | T00194 | NM_002607.2
PDGFA_transcript_variant_1 | T00195 | X06374.1
External links
LocusLink 5154
RefSeq NM_002607 | NP_002598
NM_033023 | NP_148983
GenBank AJ238420 [genome]
M19984 [genome]
M19985 [genome]
M19986 [genome]
M19987 [genome]
M19988 [genome]
M19989 [genome]
M20488 [genome]
M20489 [genome]
M20490 [genome]
M20491 [genome]
M20492 [genome]
M20493 [genome]
M20494 [genome]
M21571 [genome]
M59423 [genome]
M83575 [genome]
S50869 [genome]
S51624 [genome]
S62078 [genome]
X03795 [mRNA]
X06374 [mRNA]
PubMed 14997209, 14705808, 14633628, 14573617, 12972619, 12850832, 12670444, 12645527, 12615918, 12576295, 12411321, 3754619, 3666150, 3422746, 2842868, 2832727, 1505216
Affymetrix GeneChip U133A
U133B
U95A|1109_s_at
U95A|35703_at
Transcript Sequence(s)
>T00194 Gene_ID:GA0213,Symbol:PDGFA,Class:Known_Gene,BaseSeq:NM_002607.2
ACGCGCGCCCTGCGGAGCCCGCCCAACTCCGGCGAGCCGGGCCTGCGCCTACTCCTCCTCCTCCTCTCCCGGCGGCGGCT
GCGGCGGAGGCGCCGACTCGGCCTTGCGCCCGCCCTCAGGCCCGCGCGGGCGGCGCAGCGAGGCCCCGGGCGGCGGGTGG
TGGCTGCCAGGCGGCTCGGCCGCGGGCGCTGCCCGGCCCCGGCGAGCGGAGGGCGGAGCGCGGCGCCGGAGCCGAGGGCG
CGCCGCGGAGGGGGTGCTGGGCCGCGCTGTGCCCGGCCGGGCGGCGGCTGCAAGAGGAGGCCGGAGGCGAGCGCGGGGCC
GGCGGTGGGCGCGCAGGGCGGCTCGCAGCTCGCAGCCGGGGCCGGGCCAGGCGTTCAGGCAGGTGATCGGTGTGGCGGCG
GCGGCGGCGGCGGCCCCAGACTCCCTCCGGAGTTCTTCTTGGGGCTGATGTCCGCAAATATGCAGAATTACCGGCCGGGT
CGCTCCTGAAGCCAGCGCGGGGAGCGAGCGCGGCGGCGGCCAGCACCGGGAACGCACCGAGGAAGAAGCCCAGCCCCCGC
CCTCCGCCCCTTCCGTCCCCACCCCCTACCCGGCGGCCCAGGAGGCTCCCCGGCTGCGGCGCGCACTCCCTGTTTCTCCT
CCTCCTGGCTGGCGCTGCCTGCCTCTCCGCACTCACTGCTCGCCGGGCGCCGTCCGCCAGCTCCGTGCTCCCCGCGCCAC
CCTCCTCCGGGCCGCGCTCCCTAAGGGATGGTACTGAATTTCGCCGCCACAGGAGACCGGCTGGAGCGCCCGCCCCGCGC
CTCGCCTCTCCTCCGAGCAGCCAGCGCCTCGGGACGCGATGAGGACCTTGGCTTGCCTGCTGCTCCTCGGCTGCGGATAC
CTCGCCCATGTTCTGGCCGAGGAAGCCGAGATCCCCCGCGAGGTGATCGAGAGGCTGGCCCGCAGTCAGATCCACAGCAT
CCGGGACCTCCAGCGACTCCTGGAGATAGACTCCGTAGGGAGTGAGGATTCTTTGGACACCAGCCTGAGAGCTCACGGGG
TCCACGCCACTAAGCATGTGCCCGAGAAGCGGCCCCTGCCCATTCGGAGGAAGAGAAGCATCGAGGAAGCTGTCCCCGCT
GTCTGCAAGACCAGGACGGTCATTTACGAGATTCCTCGGAGTCAGGTCGACCCCACGTCCGCCAACTTCCTGATCTGGCC
CCCGTGCGTGGAGGTGAAACGCTGCACCGGCTGCTGCAACACGAGCAGTGTCAAGTGCCAGCCCTCCCGCGTCCACCACC
GCAGCGTCAAGGTGGCCAAGGTGGAATACGTCAGGAAGAAGCCAAAATTAAAAGAAGTCCAGGTGAGGTTAGAGGAGCAT
TTGGAGTGCGCCTGCGCGACCACAAGCCTGAATCCGGATTATCGGGAAGAGGACACGGGAAGGCCTAGGGAGTCAGGTAA
AAAACGGAAAAGAAAAAGGTTAAAACCCACCTAAGATGTGAGGTGAGGATGAGCCGCAGCCCTTTCCTGGGACATGGATG
TACATGGCGTGTTACATTCCTGAACCTACTATGTACGGTGCTTTATTGCCAGTGTGCGGTCTTTGTTCTCCTCCGTGAAA
AACTGTGTCCGAGAACACTCGGGAGAACAAAGAGACAGTGCACATTTGTTTAATGTGACATCAAAGCAAGTATTGTAGCA
CTCGGTGAAGCAGTAAGAAGCTTCCTTGTCAAAAAGAGAGAGAGAGAGAGAGAGAGAGAAAACAAAACCACAAATGACAA
AAACAAAACGGACTCACAAAAATATCTAAACTCGATGAGATGGAGGGTCGCCCCGTGGGATGGAAGTGCAGAGGTCTCAG
CAGACTGGATTTCTGTCCGGGTGGTCACAGGTGCTTTTTTGCCGAGGATGCAGAGCCTGCTTTGGGAACGACTCCAGAGG
GGTGCTGGTGGGCTCTGCAGGGCCCGCAGGAAGCAGGAATGTCTTGGAAACCGCCACGCGAACTTTAGAAACCACACCTC
CTCGCTGTAGTATTTAAGCCCATACAGAAACCTTCCTGAGAGCCTTAAGTGGTTTTTTTTTTTGTTTTTGTTTTGTTTTT
TTTTTTTTTGTTTTTTTTTTTTTTTTTTTTTTTTACACCATAAAGTGATTATTAAGCTTCCTTTTACTCTTTGGCTAGCT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAATTATCTCTTGGATGACATTTACACCGATAACACACAGGCTGCTGTAAC
TGTCAGGACAGTGCGACGGTATTTTTCCTAGCAAGATGCAAACTAATGAGATGTATTAAAATAAACATGGTATACCTACC
TATGCATCATTTCCTAAATGTTTCTGGCTTTGTGTTTCTCCCTTACCCTGCTTTATTTGTTAATTTAAGCCATTTTGAAA
GAACTATGCGTCAACCAATCGTACGCCGTCCCTGCGGCACCTGCCCCAGAGCCCGTTTGTGGCTGAGTGACAACTTGTTC
CCCGCAGTGCACACCTAGAATGCTGTGTTCCCACGCGGCACGTGAGATGCATTGCCGCTTCTGTCTGTGTTGTTGGTGTG
CCCTGGTGCCGTGGTGGCGGTCACTCCCTCTGCTGCCAGTGTTTGGACAGAACCCAAATTCTTTATTTTTGGTAAGATAT
TGTGCTTTACCTGTATTAACAGAAATGTGTGTGTGTGGTTTGTTTTTTTGTAAAGGTGAAGTTTGTATGTTTACCTAATA
TTACCTGTTTTGTATACCTGAGAGCCTGCTATGTTCTTCTTTTGTTGATCCAAAATTAAAAAAAAAATACCACCAAC

>T00195 Gene_ID:GA0213,Symbol:PDGFA_transcript_variant_1,Class:Known_Gene,BaseSeq:X06374.1
TTCTTGGGGCTGATGTCCGCAAATATGCAGAATTACCGGCCGGGTCGCTCCTGAAGCCAGCGCGGGGAGCGAGCGCGGCG
GCGGCCAGCACCGGGAACGCACCGAGGAAGAAGCCCAGCCCCCGCCCTCCGCCCCTTCCGTCCCCACCCCCTACCCGGCG
GCCCAGGAGGCTCCCCGGCTGCGGCGCGCACTCCCTGTTTCTCCTCCTCCTGGCTGGCGCTGCCTGCCTCTCCGCACTCA
CTGCTCGCCGGGCGCCGTCCGCCAGCTCCGTGCTCCCCGCGCCACCCTCCTCCGGGCCGCGCTCCCTAAGGGATGGTACT
GAATTTCGCCGCCACAGGAGACCGGCTGGAGCGCCCGCCCCGCGCCTCGCCTCTCCTCCGAGCAGCCAGCGCCTCGGGAC
GCGATGAGGACCTTGGCTTGCCTGCTGCTCCTCGGCTGCGGATACCTCGCCCATGTTCTGGCCGAGGAAGCCGAGATCCC
CCGCGAGGTGATCGAGAGGCTGGCCCGCAGTCAGATCCACAGCATCCGGGACCTCCAGCGACTCCTGGAGATAGACTCCG
TAGGGAGTGAGGATTCTTTGGACACCAGCCTGAGAGCTCACGGGGTCCACGCCACTAAGCATGTGCCCGAGAAGCGGCCC
CTGCCCATTCGGAGGAAGAGAAGCATCGAGGAAGCTGTCCCCGCTGTCTGCAAGACCAGGACGGTCATTTACGAGATTCC
TCGGAGTCAGGTCGACCCCACGTCCGCCAACTTCCTGATCTGGCCCCCGTGCGTGGAGGTGAAACGCTGCACCGGCTGCT
GCAACACGAGCAGTGTCAAGTGCCAGCCCTCCCGCGTCCACCACCGCAGCGTCAAGGTGGCCAAGGTGGAATACGTCAGG
AAGAAGCCAAAATTAAAAGAAGTCCAGGTGAGGTTAGAGGAGCATTTGGAGTGCGCCTGCGCGACCACAAGCCTGAATCC
GGATTATCGGGAAGAGGACACGGATGTGAGGTGAGGATGAGCCGCAGCCCTTTCCTGGGACATGGATGTACATGGCGTGT
TACATTCCTGAACCTACTATGTACGGTGCTTTATTGCCAGTGTGCGGTCTTTGTTCTCCTCCGTGAAAAACTGTGTCCGA
GAACACTCGGGAGAACAAAGAGACAGTGCACATTTGTTTAATGTGACATCAAAGCAAGTATTGTAGCACTCGGTGAAGCA
GTAAGAAGCTTCCTTGTCAAAAAGAGAGAGAGAGAGAGAGAGAGAGAAAACAAAACCACAAATGACAAAAACAAAACGGA
CTCACAAAAATATCTAAACTCGATGAGATGGAGGGTCGCCCCGTGGGATGGAAGTGCAGAGGTCTCAGCAGACTGGATTT
CTGTCCGGGTGGTCACAGGTGCTTTTTTGCCGAGGATGCAGAGCCTGCTTTGGGAACGACTCCAGAGGGGTGCTGGTGGG
CTCTGCAGGGCCCGCAGGAAGCAGGAATGTCTTGGAAACCGCCACGCGAACTTTAGAAACCACACCTCCTCGCTGTAGTA
TTTAAGCCCATACAGAAACCTTCCTGAGAGCCTTAAGTGGTTTTTTTTTTTGTTTTTGTTTTGTTTTTTTTTTTTTTGTT
TTTTTTTTTTTTTTTTTTTTTTACACCATAAAGTGATTATTAAGCTTCCTTTTACTCTTTGGCTAGCTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTAATTATCTCTTGGATGACATTTACACCGATAACACACAGGCTGCTGTAACTGTCAGGACAGT
GCGACGGTATTTTTCCTAGCAAGATGCAAACTAATGAGATGTATTAAAATAAACATGGTATACCTACCTATGCATCATTT
CCTAAATGTTTCTGGCTTTGTGTTTCTCCCTTACCCTGCTTTATTTGTTAATTTAAGCCATTTTGAAAGAACTATGCGTC
AACCAATCGTACGCCGTCCCTGCGGCACCTGCCCCAGAGCCCGTTTGTGGCTGAGTGACAACTTGTTCCCCGCAGTGCAC
ACCTAGAATGCTGTGTTCCCACGCGGCACGTGAGATGCATTGCCGCTTCTGTCTGTGTTGTTGGTGTGCCCTGGTGCCGT
GGTGGCGGTCACTCCCTCTGCTGCCAGTGTTTGGACAGAACCCAAATTCTTTATTTTTGGTAAGATATTGTGCTTTACCT
GTATTAACAGAAATGTGTGTGTGTGGTTTGTTTTTTTGTAAAGGTGAAGTTTGTATGTTTACCTAATATTACCTGTTTTG
TATACCTGAGAGCCTGCTATGTTCTTCTTTTGTTGATCCAAAATTAAAAAAAAAATACCACCAAC

Note: Some data originated from NCBI's LocusLink.